Material from the human lung is particularly valuable for translational research: it is essential for testing and understanding the mechanisms of the highly diverse pulmonary diseases, such as chronic obstructive pulmonary disease (COPD), pulmonary hypertension, pulmonary fibrosis or others.
Due to its exceptional importance, a separate platform for pulmonary pathology was established within the BREATH research network in 2014. This platform is based at Hannover Medical School (MHH), one of the largest lung transplant centers in the world, and provides clinicians and researchers in the German Center for Lung Research (DZL) with a sophisticated logistics system (including 24h on-call service and processing of fresh material / 7 days a week), the latest histopathological and molecular pathological diagnostics and valuable lung material of outstanding quality.
The Pulmonary Pathology research team at the MHH, with its 15 members, deals intensively with tumor diseases, alterations in the lung occurring in various diseases, and also with pulmonary hypertension. Linking clinically relevant issues with the morphology of tissues and the molecular pathology of the lung is the main focus of the research.
From the main research topics:
- Morphological and molecular characterization of the non-small cell bronchial carcinoma (Project Leader: Dr. Florian Länger),
- Fibrotic remodeling and experimental pathology of the lung (Project Leaders: PD Dr. Danny Jonigk and Dr. Florian Länger) and
- Pulmonary hypertension (Project Leader: PD Dr. Danny Jonigk),
a number of continuing national and international projects and cooperations have been established at BREATH, in which, among other things, fresh tissue from explant recipient lungs is used in interdisciplinary projects to find an answer to diverse issues.